As proof that we have so much more to learn about cannabis, it has been announced that a team of researchers from Italy has discovered two new cannabinoids that may be even more potent than THC and CBD. The cannabinoids THCP (tetrahydrocannabiphorol) and CBDP (cannabidiphorol) were discovered by an Italian team and published in Nature a few weeks ago. This represents a major milestone in the field of medical marijuana research.
The presence of this new phytocannabinoid could account for the pharmacological properties of some cannabis varieties difficult to explain by the presence of the sole Δ9-THC. https://www.nature.com/articles/s41598-019-56785-1 Citti, C., Linciano, P., Russo, F. et al. A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol. Sci Rep9, 20335 (2019) doi:10.1038/s41598-019-56785-1
This is the same team that identified two other new cannabinoids, THCB and CBDB, last year.
Meet the Two New Cannabinoids
“The first, tetrahydrocannabiphorol (THCP), is allegedly 30 times more potent than THC, they claim. Whether that means it gets you 30 times as stoned—or if it’s even psychoactive at all—is still unknown. But in mice, it appeared THCP was more active than THC at lower doses. The scientists also found cannabidiphorol (CBDP), a cousin to CBD…” https://www.vice.com/en_us/article/akwd85/scientists-discover-two-new-cannabinoids
Unfortunately the team used a variety called FM2 which is grown by the Italian military and has low levels of THC , so the new cannabinoids were found in relatively small quantities. We wish that the government would start researching cannabis using strains that people actually use and enjoy every day. Why not ask the people that have been producing the cannabis that actually works and is enjoyed by millions instead of obscure strains that were actually designed to stifle any productive research by failed drug war entities like the military and the DEA?
A new study has made some revealing discoveries about the cannabis grown at the University of Mississippi. That’s the infamous and sole source of cannabis being used in federally funded cannabis research… That Ole Miss weed, which is funded by the National Institute On Drug Abuse (NIDA), is clearly not representative of what anyone in the real world is smoking/processing, and despite numerous requests to the Justice Department to expand the options for researchers to obtain cannabis from other, better sources, NIDA remains the solitary hook-up for federally funded researchers.https://www.thestranger.com/slog/2019/04/03/39805066/the-cannabis-used-for-federally-funded-research-barely-qualifies-as-cannabis
At the current time I wouldn’t expect to see these cannabinoids on any packaging or test results because they were only discovered using cutting edge spectometry that is not widely available for commercial use. The discovery of these cannabinoids implies that the test results we often look to as indicators of potency may not be as reliable as we thought. In other words, strains that have ostensibly lower THC levels may in fact seem more potent to the end user because of the presence of THCP which does not appear in current testing.
One critical implication the study stresses is that THCP could account for why cannabis can provoke such disparate experiences in consumers. As the researchers took care to emphasize, there’s an astonishing variability of subject response to cannabis-based therapies, even with equal doses of THC. https://www.leafly.com/news/science-tech/thcp-cbdp-study-reveals-identification-two-new-cannabinoids
Imagine what else might be discovered if research was undertaken using quality strains that are available to the general public instead of sub-standard strains that barely qualify as cannabis.